After the death of her father, Peni Parker inherited the experimental mech-suit known as SP//dr. In order to control the suit, Peni had to allow herself to be bitten by the irradiated arachnid that controls its CPU, forming a psychic bond between them.

Now, Peni and SP//dr keep the people of Shin-Shibuya safe, just like her father did before her. But their mission is bigger than just one city. Since the Timestream Entanglement, Peni and SP//dr have devoted themselves to the protection of the Web of Life and Destiny and the countless realities it connects.